MINNEAPOLIS — When Nelson Cruz signed with the Minnesota Twins this past offseason, he made a few predictions. He was confident he would get to 400 career home runs this year, and he also believed the Twins would make the playoffs.

One down, one to go.

Cruz hit his 400th career home run, Miguel Sanó connected twice and the Twins powered past the Kansas City Royals 12-8 Sunday.

Minnesota piled up six runs in the first inning and rolled from there after starting the day with a four-game lead over Cleveland for first place in the AL Central.

Cruz became the 57th player with 400 homers. His fourth-inning solo shot was also his 40th homer of the season.

“It’s nice to do it in front of the fans. I think they deserve it,” Cruz said. “They’ve been such a big influence for us as a team. They come up every day with that energy.”

Kansas City joined Baltimore, Detroit and Miami with 100 losses, only the second time in major league history there have been four 100-loss teams in one season. In 2002, Detroit, Milwaukee and Tampa Bay each lost 106 and Kansas City was defeated for the 100th time on the season’s final day.

Cruz joined Harmon Killebrew and Brian Dozier as the only Twins to hit 40 homers in a season. He traded a baseball, a bat and a photo with the fan who caught his 400th home run in exchange for the milestone ball.

Sanó homered in the first and third innings. Sanó hit a three-run drive during the big first inning against starter Jorge López, who lasted just 2 1/3 innings.

Eddie Rosario and Marwin Gonzalez each drove in three runs for the Twins, who play their final six regular season games away from Target Field. Minnesota is 50-25 on the road.

Minnesota’s Martin Perez had his shortest start of the year. The lefty allowed five runs and eight hits in 2 1/3 innings. Zack Littell (6-0) earned the win.

Kansas City left fielder Whit Merrifield became the eighth Royal to reach 200 hits in a season.

“To get to 200 hits, it’s a huge accomplishment,” Merrifield said. “It’s a huge goal I’ve had. It’s a blessing to have stayed healthy long enough to do it — that’s a huge part of it, the durability.”

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